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The Riddle of Steel
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@neptune depends on the campaign. But tbh most dms don't want to reinvent the wheel.
I'm fairly certain she hasn't changed this because we've had conversations in-game about genetics and inbreeding, which implies DNA exists. We've also interacted with NPCs who have genetic disorders like Down Syndrome and hemophilia, which wouldn't exist without DNA.
I don't necessarily think those things follow. You can't build CRIPSR in game because half elves have a human and an elf parent, because half elves imply inheritability which implies DNA.
The rules are the rules. So you might assume oxygen exists because your character needs to breathe, and you might assume metallurgy exists because the rules say you can mine, and forge.
But you can't just say "with this facet on industryy characters downtime will be more productive than the book says". If the book says you can mine 10gp worth of ore a day, or turn 10gp of ore into twenty a day.... Then that's what the rules say.
Obviously none of this would survive rigorous scientific method as dnd is not a science simulator. Once upon a time I wanted to use Minecraft as a science simulator.... Alas.....