Dunno if it would count as depersonalisation or derealisation but I've had out of body experiences a couple of times when I've had too much. But I've also tripped when super high (too high).

I have a weird metabolism so my highs are really variable no matter how careful I am with amounts and method. Meaning I regularly end up orbiting the moon by accident. Have had some interesting trips.

I don't ever recommend being super sick, taking melatonin and weed. My dreams were really fucking weird and I slept like shit to boot lol.

I think I've become more practised at dealing with having to much as a result and my biggest takeaway is to surrender to the experience, remind yourself that it will wear off, and mindfully embrace the experience and how you're feeling, be really in the moment.