Not sure if it count but Street of Rogue is kinda like a 2d GTA or Saints Row only without the cars and there's lots of characters with completely different playstyles like you can go guns blazing as a soldier or play as a pacifist doctor who can't really fight and has to use stealth or other means to do objectives or be a gorilla rescuing other gorillas who's very strong but cant talk to people or use guns or be a zombie who weak on its own but once it gets going you'll start the zombie apocalypse.

There're also these mutators which can be used as accessibility options cause I use it to slow the game down but it can be used to turn off some of the stuff that you don't like in the game.