I was talking about this just the other day as a joke.

I would make "Car Simulator." It would simulate driving and working on a car exceptionally well. But the game itself would be basically Grand Theft Auto, just with much more realistic car control, modification and physics.

Another, serious idea, I've been kicking around a while but am unsure how to actually do it is a game that captures the insanity of solving fictional problems with fictional solutions on Star Trek. Like a nebula is sapping energy from your ship, so you reconfigure the deflector to emit a neutron pulse or something. It would simulate science itself and create random elements and physics that the player would have to learn, understand, and can exploit. The key is that it's always new and different forcing every player, every new game to be creative in coming up with solutions to the random problem with equally random tools to promote critical thinking skills. I'm just not sure how to gamify "the scientific method" itself or I'd be actively working on making this a reality.