I have an AKiTiO Node Titan eGPU enclosure with a GTX 1070 hooked up to an Ubuntu 22.04 laptop and it's working pretty well. I'm doing PCI passthrough to an Arch Linux VM, since my company mandated that all Linux users must use Ubuntu. To stave off comments about this, I'll say that it's not just that I dislike Ubuntu. They're requiring me to lock down so much stuff that I can't do my job. Plus, the endpoint security sensor on the host plays absolute hell with anything that uses heavy multiprocessing. The GPU (with external monitors), second NVMe drive, mouse, keyboard, audio interface, microphone, webcam, 30 gigs of RAM, and 11 CPU cores are passed to the VM, and the host OS gets the laptop GPU + monitor and my continuing disdain.

I've been using this setup for a month. My experience thus far has been positive. I start the computer up with or without the GPU connected, connect the GPU if I haven't yet, launch my VM via libvirt, and things just work. I really thought I'd have more problems with the GPU, but the USB passthrough stuff has been the truly problematic part (I can't just pass the whole PCI USB controller for IOMMU reasons). It's important to note that the GPU displays directly to external monitors. I think it's possible to like, send the data back to your laptop screen? But I really didn't want that.

(As an aside, the security people at my company have no problems with VMs lol. They know what I've done and they don't seem to care).