I think there are levels to it. Adblockers, while still not being used by the majority of people, has a pretty significant chunk of users and is becoming more common to regular people, not just privacy-concerned users. So I think DNS level blocking is fine. You start to stand out when you add more privacy and anonymity tools on top of it, like Decentralyes, for example.

Some people seem to think that blending in is the best/only strategy to avoid being tracked and profiled. The developer of GrapheneOS advocates for this in no uncertain terms, encouraging users of his Vanadium web browser not to use uBlock or NoScript, yet also claims that DNS-level blocking is the only way to block content without sticking out like a sore thumb. I personally question his assumptions regarding this. All it would take for a big ad broker like Google, Amazon, Baidu to detect this would be for them to analyze their web server logfiles to spot which distinct clients (IP addr. x date x time x User-Agent string x other fingerprints) connect to their front-ends but don't connect to the analytics or ad-network servers during the same page-loading time frame.

One might also wonder whether ad brokers put deals in place with their customers to get read access to these customer's web server logfiles to do the same kind of analysis in exchange for cheaper rates. Or perhaps under the guise of "let us offload you of these complicated analytics tasks, just show us your logfiles and we'll take it from there."