21
New paper explains why females are prone to autoimmune diseases
(arstechnica.com)
you are viewing a single comment's thread
view the rest of the comments
view the rest of the comments
this post was submitted on 07 Feb 2024
21 points (100.0% liked)
Medicine
1092 readers
1 users here now
This is a community for medical professionals. Please see the Medical Community Hub for other communities.
Official Lemmy community for /r/Medicine.
!medicine@mander.xyz is a virtual lounge for physicians and other medical professionals from around the world to talk about the latest advances, controversies, ask questions of each other, have a laugh, or share a difficult moment.
This is a highly moderated community. Please read the rules carefully before posting or commenting.
Related Communities
- Medical Community Hub
- Medicine (📍)
- Medicine Canada
- Premed
- Premed Canada
- Public Health
See the pinned post in the Medical Community Hub for links and descriptions. link (!medicine@lemmy.world)
Rules
Violations may result in a warning, removal, or ban based on moderator discretion. The rule numbers will correspond to those on /r/Medicine, and where differences are listed where relevant. Please also remember that instance rules for mander.xyz will also apply.
-
Flairs & Starter Comment: Lemmy does not have user flairs, but you are welcome to highlight your role in the healthcare system, however you feel is appropriate. Please also include a starter comment to explain why the link is of interest to the community and to start the conversation. Link posts without starter comments may be temporarily or permanently removed. (rule is different from /r/Medicine)
-
No requests for professional advice or general medical information: You may not solicit medical advice or share personal health anecdotes about yourself, family, acquaintances, or celebrities, seek comments on care provided by other clinicians, discuss billing disputes, or otherwise seek a professional opinion from members of the community. General queries about medical conditions, prognosis, drugs, or other medical topics from the lay public are not allowed.
-
No promotions, advertisements, surveys, or petitions: Surveys (formal or informal) and polls are not allowed on this community. You may not use the community to promote your website, channel, community, or product. Market research is not allowed. Petitions are not allowed. Advertising or spam may result in a permanent ban. Prior permission is required before posting educational material you were involved in making.
-
Link to high-quality, original research whenever possible: Posts which rely on or reference scientific data (e.g. an announcement about a medical breakthrough) should link to the original research in peer-reviewed medical journals or respectable news sources as judged by the moderators. Avoid login or paywall requirements when possible. Please submit direct links to PDFs as text/self posts with the link in the text. Sensationalized titles, misrepresentation of results, or promotion of blatantly bad science may lead to removal.
-
Act professionally and decently: /c/medicine is a public forum that represents the medical community and comments should reflect this. Please keep disagreement civil and focused on issues. Trolling, abuse, and insults (either personal or aimed at a specific group) are not allowed. Do not attack other users' flair. Keep offensive language to a minimum and do not use ethnic, sexual, or other slurs. Posts, comments, or private messages violating Reddit's content policy will be removed and reported to site administration.
-
No personal agendas: Users who primarily post or comment on a single pet issue on this community (as judged by moderators) will be asked to broaden participation or leave. Comments from users who appear on this community only to discuss a specific political topic, medical condition, health care role, or similar single-topic issues will be removed. Comments which deviate from the topic of a thread to interject an unrelated personal opinion (e.g. politics) or steer the conversation to their pet issue will be removed.
-
Protect patient confidentiality: Posting protected health information may result in an immediate ban. Please anonymize cases and remove any patient-identifiable information. For health information arising from the United States, follow the HIPAA Privacy Rule's De-Identification Standard.
-
No careers or homework questions: Questions relating to medical school admissions, courses or exams should be asked elsewhere. Links to medical training communitys and a compilation of careers and specialty threads are available on the /r/medicine wiki. Medical career advice may be asked. (rule is different from /r/Medicine)
-
Throwaway accounts: There are currently no limits on account age or 'karma'. (rule is different from /r/Medicine)
-
No memes or low-effort posts: Memes, image links (including social media screenshots), images of text, or other low-effort posts or comments are not allowed. Videos require a text post or starter comment that summarizes the video and provides context.
-
No Covid misinformation, conspiracy theories, or other nonsense
Moderators may act with their judgement beyond the scope of these rules to maintain the quality of the community. If your post doesn't show up shortly after posting, make sure that it meets our posting criteria. If it does, please message a moderator with a link to your post and explanation. You are free to message the moderation team for a second opinion on moderator actions.
founded 2 years ago
MODERATORS
This is the best summary I could come up with:
There is evidence suggesting that it's females’ double complement of X chromosomes that puts them at such heightened risk for autoimmune diseases.
One suggestion for why women are more susceptible to autoimmune disease is the pregnancy-compensation hypothesis, which posits that women’s immune systems have to be super vigilant to cope with the potentially dangerous foreign bodies that got implanted in them regularly and frequently throughout human history (placentas and fetuses).
Now, women have birth control and don’t spend most of their adult lives pregnant, but their overactive immune systems haven’t yet learned to calibrate, the idea goes, so they attack the body's own tissues.
Thirty Xist binding proteins have already been reported to be targets of antibodies in human autoimmune diseases, which is what spurred this study in the first place.
Physicians and scientists have long known that (1) women get more autoimmune diseases than men; (2) dosage compensation for the second X chromosome in female cells likely played some role in that; (3) RNA-protein complexes are often targeted by autoantibodies; and (4) Xist is part of an RNA-protein complex involved in X inactivation.
Hopefully, this research will reveal some new and effective targets for the diagnosis, monitoring, stratification, and treatment of this suite of diseases.
The original article contains 666 words, the summary contains 206 words. Saved 69%. I'm a bot and I'm open source!