Large scale wise, Doctors without Borders, World Health Organization, and the organizations that help fight for/track sex trafficked people to liberate them.

And within the US (I'm sure there's others, I'm a yank so my understanding of how things in Germany/Canada/China/South Africa go is often poor) there's the Electric Frontier Foundation, Meals on Wheels, Planned Parenthood, American Society for the Prevention of Cruelty to Animals, and a lot more that help most citizens and biological beings get the right to, life, liberty, and the pursuit of happiness that isn't actually given by any government.

Also Child's Play and Make a Wish Foundation are pretty good for sick children to get some levity in a harsh childhood. I usually chip in some online donations/sale credits to Child's Play and EFF so that they have entertainment when stuck in a hospital, and more digital rights for when they get out of it.