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It absolutely matters whether you're managing your depression with alcohol or antidepressants because one of those two is enormously more dangerous than the other
Especially dangerous together.
Ehh, depends on what you're taking and why. I like alcohol (in moderation, of course) but when I wasn't properly medicated for my depression, I'd find my mind wandering to dark places if I had some. Now that I'm doing a bit better thanks to the medicine, and the medicine in question doesn't have any bad interactions with alcohol, I can actually enjoy a drink again.