When you have a bunch of computers networked, each of them is assigned a unique number, so when other computers send data on the wire, they can say who it is meant for (imagine each blurb of data starting out like: "yo, I'm sending these next 500 bytes for computer 0A123FBC32, here they come").

Now the right computer will listen, but it doesn't know what program the data is for - is it a chunk of a file your browser is downloading? Or the email your email app wants to display? Or perhaps a join request from your buddy's computer for the Minecraft game you're hosting?

So in addition to the unique number of the target computer, the data also specifies a "port number", which tells the computer which of its running programs the data is meant for (programs ask the computer's operating system: "if any network data arrives on port XY, give it to me"). Some ports have become standards - for example, a program that serves web pages to other computers would typically ask the operating system that any data arriving on the computer that indicates port numbers 80 and 443 should be given to it, and when a web browser wants to fetch a web page, it will send a request to the computer serving the page, defaulting to port 80 o 443.

If you dig deeper, you'll find that there are even more unique numbers involved and routers/firewalls let data through not only by port number but also by distinguishing between data that is the initial request to another computer's port number and data that is an answer to an earlier seen request -- and more.