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Not sure if it's the same with poison ivy, but with Poison oak true immunity is rare/difficult to achieve. I had one co worker who believed he was immune to po for years until he got the oil in an open gash and the infection went systemic. After that, he got po rashes like the rest of us. True immunity does seem to be possible though, I know a few people who have completely immunized themselves with an extremely careful and specific tea regimen