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Ketamine is actually great for treatment resistant depression. Lotta ignorant people in the comments. Fuck the corpos and their nonsense to avoid treating workers with human decency, but ketamine prescribed correctly is actually quite effective.
It can be quite expensive, but after 20 different antidepressants and antipsychotics, I've considered it. My latest medications were $1738/m and $1800/m respectively. That's like $60 per pill that I need to take daily. I'm in a fortunate position with amazing health insurance that will cover it.
Ketamine is $1200 every 3 months, includes therapy, and has cheaper daily nasal spray to maintain the treatment.
Also, recreational Ketamine is different. There's Ketamine (recreational) and S-Ketamine (therapeutic). It does absolutely give you psychedelic effects, but it wouldn't be as fun of a thing to take in your spare time as Ketamine.
Does it have to be dosed a certain way, because I've only ever tried it recreationally and it didn't do anything for my depression. The euphoria wore off very quickly, and tolerance built rapidly. The whole experience lasted less than 20 minutes, IIRC, with no "afterglow" unlike with psychedelics and MDMA. Very short trip and then back to normal. Redosing was futile.
I think it may be a spinal tap, though I am quite unsure about dosing.