90
State of S3 - Your Laptop is no Laptop anymore
(blog.jeujeus.de)
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Nothing with a recent AMD gfx Card or APU will officially support S3, and I think Nvidia is the same. Just because it isn't supported doesn't mean they'll intentionally break anything, but over time you'll have more and more bugs related to it and one day it will break and never be fixed.
Personally I use S4 (hibernate) more or less exclusively.