The couple of months of frustration needed to learn Dvorak were totally worth it, even with the keyboard layout issues I've had to deal with since then, like remembering to switch if a game doesn't automatically remap their keys for dvorak or finding out how to switch layouts when MS has yet again changed where the option is.

Better comfort, plus an extra layer of security vs people watching what you type to guess a password. Plus some potential to trick keyloggers that use raw keyboard input but don't consider alternate layouts, though that's a pretty easy flaw to correct it they do realize why it all looks like a jumbled mess.