Blender is currently the #1 general-purpose 3d editor.... short of Houdini but it's getting there with everything nodes and when people complain about Blender being complicated or such they usually don't compare it against Houdini.

Sure, sculptors love ZBrush but ZBrush doesn't let you sculpt with full lightning and everything it doesn't even begin to support it because it's so specialised, arguably it's not even a 3d program (but 2.5d). Blender might only get to 95% of what sculptors might wish for but because it also does everything else you suddenly get another 50% that sculptors didn't even dream of. If you just bought your first tablet definitely give Blender a spin (also Krita over Photoshop).

As to Blender's UI, there's pretty much only three mistakes you can make: a) Assume that this could ever be mastered without a manual, discovered as you go without setting time aside to study it for its own sake, b) fall to the dark side and use left-click select and c) not customise things. Blender has more functions than could possibly fit on key combinations, supports more different workflows than it has users so once you've figured out a workflow customise the UI to be efficient for that particular flow.

Side note: Have you considered Blender as a vector editor?