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Is there an age where you decide to just 'let it go'?
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My grandfather in law died now at 93. He smoked for a long time. Died of COPD. With modern science and healthcare he could have lived longer. But smoking really fucked up his lungs and his oxygen uptake even from oxygen tanks became so degraded, he just stopped waking up from long naps. Now here's the fun part. He stopped smoking when he was 55. But he started when he was 13. 42 years of smoking. And then afterwards 38 years of not smoking.
The damage is irreversible.