I definitely have, but can't remember which off the top of my head. Looking at other comments, Ori and Stray are likely on the list. But I cry at movies too (off the top of my head Artificial Intelligence, The Bionic Man, Cloud Atlas, The Other Sister) and even books (bawled at Gloriously Bright's story in Xenocide).

RDR2 almost did that to me at the end

Loom but I don't recall why.

my characters die hundreds of times, can't get emotionally attached

My brother beat me at Pipemania, so I put my foot through a glass door panel.

Have never cried because of a video game,

I was absolutely stunned and amazed when Ted Faro revealed what Zero Dawn really was in Horizon Zero Dawn.

I cried when I wasn't able to play League of Legends anymore because of Vanguard.

Other than that, I think I cried a little with Life is Strange.

A lot actually, I'm quite sensitive to emotional things. I've been playing Honkai Impact 3rd and it's made me tear up multiple times. I don't remember all of the games but some of the other games I remember are:

All of the Kingdom Hearts except "3D" and 3 because I haven't played them yet.

Metal Gear solid 1, 2, 3 and Peace Walker

Some of the Final Fantasy games

Castlevania Order of Ecclesia

I think Yakuza/Like a Dragon wins the crown for game series that's made me emotional the most times. Majima seeing Makoto in the ending of 0 and in 2, Kiryu seeing the message the orphanage kids left him in The Man Who Erased His Name, Kiryu going on a tour of his old haunts in Infinite Wealth, Majima visiting Kiryu in the hospital at the end of Pirate Yakuza in Hawaii...there are plenty more, but those all came to mind. They really use the fact that we've been following these characters for decades to the fullest extent.

lol no.

I have sensitive eyes. Any modern AAA graphics makes them go red instantly and my eyes start leaking within 30 minutes.

Brother's got me ugly crying

Yep. I play FFXIV and I'm on estrogen. I cry basically every major patch cycle.