I did a book collection run once. Collect as many unique books as possible in a single run. I got about 94% of the books in the game, which is as many as I think you can get in a single run. The remaining 6% is locked behind story branches that would eat into the 94% I did get.

And honestly? It wasn't that fun. I had to scour rooftops, look around in vases, cross-reference the wiki, reload the game because I made a wrong choice that seemed like a nothing choice at the time... And all I got were some notes. And they weren't even much better than the ones you get in a normal run.

And this was just books. I had to skip Gale's content entirely just to collect an extra note. There is a robe you can only get if you kill Karlach. There's simply too many branches for you to get everything.

You can't get 100%. You might be able to get 95%, but it won't be fun. From now on, I'll just clear the map markers before moving on, and that'll be enough for me.

Ha! Yeah, I mean no discouragement but I don't think the devs designed you to do everything in one run. I mean, there are certain items that you can't get unless certain important characters die. If you really wanted to collect everything that could be collected (just usable items, not junk) I imagine you'd have to play through the whole game 6 or more times.

It’s not possible. I’ve got 1500 hours in this game and i was still finding random shit 1000 hours in. Just play a campaign knowing that you’ll need to play it at least three or four times to see most of the quests and outcomes. At least once as dark urge since that storyline is very different.

Do you guys collect barrels and chests?

There have been times where I go to camp and back to build towers to get to diffident areas.