Most self hosted DNS level blocking will be very fast as it is really easy to keep the block list in RAM. I hosted Pi Hole on RPi 3 and an over provisioned VM (4 cores and 4GB of ram lol). The only difference I’ve noticed is whether or not the device is hardwired. When my RPi was hardwired into the network, there was no notable difference between the two.

Performance is usually pretty similar. I use AdGuard Home (mostly for malware blocking) and it stores the cache in RAM, so the only thing that's potentially slow is the first lookup for a domain. That's going to be affected by the size of your block list, but it's likely that all these solutions use hashing to speed it up, meaning it won't slow down linearly. Once a domain is cached, serving it is very fast. The others work similarly.

AdGuard Home has an option to serve a stale cached record and refresh it in the background, meaning DNS lookups will practically always be served from RAM, except after you restart it when the RAM cache is empty.

I also like AdGuard Home because it supports DNS over HTTPS and DNS over TLS, and uses it by default. There's also a separate piece of software called AdGuardHome-Sync to keep the config in sync between multiple instances. I run two of them (one on a home server in Docker, and one on a Raspberry Pi in Docker) so I can take one down without breaking the internet for my wife.

Acronyms, initialisms, abbreviations, contractions, and other phrases which expand to something larger, that I've seen in this thread:

4 acronyms in this thread; the most compressed thread commented on today has 9 acronyms.

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All DNS blocking is going to be very fast, essentially no real added time.