Whichever you're more comfortable with and provides the features you want.
Define "sandboxed"
Application can only access a limited part of the system? = use flatpak or build a container/VM image using the nix pkgs.
Application can be uninstalled completely and has separate libraries? I prefer nix.
Nix apps are not sandboxed and you have no control of what resources they have access to or don't, unless you wrap them with some other program
I'd say Nix requires some experience, so if you are new to Linux, definitely go with Flatpak. I believe Flatpak also provides stronger sandboxing.
Flatpaks are easier to use in most distros. If you're using NixOS, then Nix of course. But if you want to do a lot of CLI stuff, then Nix may be better too.
Linux
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Linux is a family of open source Unix-like operating systems based on the Linux kernel, an operating system kernel first released on September 17, 1991 by Linus Torvalds. Linux is typically packaged in a Linux distribution (or distro for short).
Distributions include the Linux kernel and supporting system software and libraries, many of which are provided by the GNU Project. Many Linux distributions use the word "Linux" in their name, but the Free Software Foundation uses the name GNU/Linux to emphasize the importance of GNU software, causing some controversy.
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