Naomi in The Expanse when she's trapped on a ship

Stellan Skarsgård acting as Luthen on Andor during his monologue about being the rebel leader and the effect its had on his life.

When Buffy Summers found her mom dead on the couch.

Bella Ramsey as Lyanna Mormont, pleading for the king of the north. Plenty more, but this one came to mind

Bill and Frank in ep3 of The Last of Us.

Someone else already mentioned it: Luthen’s speech in Andor.

Andre Bougher and Andy Samberg at the end of Brooklyn 99 episode "The Box". After a long night of interrogating a suspect, they emerge only to realize that it's already morning of the next day and they have this extremely honest moment of father figure and son.

Coin-toss scene

I've always loved this scene. Both actors are killing it. Friend-o

Oh, let's not forget Paddy Considine's entire season as Viserys in House of the Dragon

Patrick Stewart at the end of "The Inner Light" (the flute episode). Man looks as traumatised as I feel someone would be. It's all done with his face.

https://youtu.be/0UGuPvrsG3E

Absolutely brilliant.

Portia Doubleday and Rami Malek in almost every scene together in Mr Robot. That whole cast really was incredible.

John Spencer's scene as Leo McGarry describing being an alcoholic.

Patrick Stewart's Captain Picard trying to teach Brent Spiner's Data how to play poker at the beginning of Picard.

Mike Ehrmantraut's sofa monologue about his son in Better Call Saul

1. Dave Annable in Lioness, telling his daughter that

   Tap for spoiler

   Her friend died in the car accident, and also she’s pregnant but the baby might not make it

2. Billy Bob Thornton’s every word and action in the episode of 1883 that he guest stars in.