[-] bandario@lemmy.dbzer0.com 10 points 1 year ago

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976712/

It's significant. Biggest effect is on efficacy of drug metabolism. There are many such studies.

One size does not fit all here owing to differences in expression of metabolising enzymes and drug transport mechanisms.

No, the Japanese are not aliens but they may require far less of a given drug than a westerner, or far more. This affects the likelihood to experience side effects for any given compound, and their severity.

It's fairly ironic to make this change for Japan whilst elsewhere in the world with more racially mixed populations there has been a push in the opposite direction: a recognition that you cannot assume the results of a trial carried out on white male subjects will apply to those of African descent for example.

It's not just drug treatments either. There are many aspects of medical care which have suffered from a lack of specificity and systemic bias.

[-] bandario@lemmy.dbzer0.com 10 points 1 year ago

Newsgroups are bloody horrific unless you are picking things up the very second that they're released.

Everything gets DMCA takedown strikes extremely quickly and goes missing. You might get lucky and put it together with repair files etc but I have all but given up on it. You need a lightning fast connection and radarr/ sonarr set up to grab things you MIGHT be interested in automatically or it's a total wash.

[-] bandario@lemmy.dbzer0.com 10 points 1 year ago

Protest is now illegal. You will be brutally bashed by the police and locked up regardless how just the cause.

They are and have always been the blunt instrument with which the state monopoly on violence is maintained and exercised.

We are also subject to random roadside tax extortion based on whatever the fiction of the day happens to be. I would actually prefer the open faced honest corruption of simply being asked for a bribe to go on with my day ala India or Thailand. At least we don't need to pretend the interaction is anything other than what it is.

[-] bandario@lemmy.dbzer0.com 10 points 1 year ago

Do you know how many god damn houses I could build with 10 billion dollars?

SO MANY FUCKING HOUSES, BECAUSE THEY'D ALL BE WELL-BUILT APARTMENTS.

Why do I feel like this is somehow going to achieve somewhere between diddly squat and fuck-all?

[-] bandario@lemmy.dbzer0.com 10 points 1 year ago

Mix blended oysters with your polymer (for the smell), 3D print a stinky receptacle for your smelly shits whilst you eat fresh oysters.

[-] bandario@lemmy.dbzer0.com 10 points 1 year ago

lol - dude, they measure so many logs. Even with all the modern tech and fern gully esk death machines, it's still a battle to keep 10 different products within their very specific cut windows.

[-] bandario@lemmy.dbzer0.com 10 points 1 year ago

Closed because I am a mammal and I indulge in the nesting instinct.

[-] bandario@lemmy.dbzer0.com 10 points 1 year ago

is there anything they can really do to make their services work?

Once upon a time we had netflix. Almost everything you could want to watch was on there because they were just about the only show in town. During that time there was precious little reason to download most shows.

Now in order to have access to the thing you want to watch, you're expected to pay for 5 or 6 separate streaming services, by which point you end up at the same insane price point as paying for the full package of cable/PayTV channels.

They had a good thing and they ruined it with greed, just like everything else under capitalism. Glorious state streaming network should be only show in town, comrade.

[-] bandario@lemmy.dbzer0.com 10 points 1 year ago

Its truly bizarre behaviour. Like some kind of psychological phenomenon where the company don't want their time wasted by tyre kickers who aren't serious.

Works both ways though. Put your prices up or I will just assume you aren't competitive and skip you.

[-] bandario@lemmy.dbzer0.com 10 points 1 year ago

Absolutely. I'll take you on a very brief journey through the years. I will forewarn you: most people don't gel with a lot of this stuff unless they have had a head full of psychedelics on a packed dancefloor a few times to figure it all out so we start gentle. You don't really dance to the beat...it's the rolling bassline you've got to jump on ;)

Medicine Drum - Suraya Mela E.P from 1996 is pure psychedelic: something approximating a distillation of goa trance mixed with tribal rhythms. If I'm not mistaken, all of the synths are analogue. It has a super organic vibe and is one of my favourites for hosting a mushroom session.

Taking a wild leap forward in time and intensity: Raz - Twisted Fairytale (2007) Purest of Israeli psychedelic trance IMO. There's not much else to say - as far as the Isra style psytrance of this period, this is the pinnacle in my humble opinion.

Day Din - Speakers Corner (2007) Beautiful album

Tuk - The Laws of Nature (2010) This my favourite type of psychedelic release: one that is meant to be listened to as an album. This is not a dancefloor banger compilation, but a skilled DJ can string together some of the purest searing acid basslines ever recorded into a set using nothing but two copies of this CD if they wanted. It is one of my all time favourites.

Now for some proper bangers:

Nights of the Psychedelic Order Compiled by Panayota (2012) There's not much to say. It's fat, it pumps hard from start to finish and any given track on it could fill a bush dancefloor.

My finger has not been on the pulse the last 10 years. There's been some really great releases but I've no idea where they fit in; someone else can probably give you some great recommendations for newer stuff.

If you are after something a little slower, check out:

Tetrameth - Psychological Pyrotechnics, pretty much anything by Terrafractyl, god there's so much!

Hope you find something you like in there.

[-] bandario@lemmy.dbzer0.com 10 points 1 year ago

My dad is 66. He still games every day. Go dad! He's just about to fully complete fallout 4. Fuck anyone who doesn't get it, their opinions don't matter. Do what makes you happy.

[-] bandario@lemmy.dbzer0.com 10 points 1 year ago

You want to know what's truly disturbing? The previous Australian Federal government did many of these same things too, or worse.

It seems true democracy has fallen out of favour.

view more: ‹ prev next ›

bandario

joined 1 year ago