[-] fullsquare@awful.systems 2 points 5 days ago* (last edited 5 days ago)

that's at least four days before kidnapping of maduro

op what else did you knew

[-] fullsquare@awful.systems 2 points 5 days ago* (last edited 5 days ago)

dune (1965) was written 26 years before desert storm (1991) and before iran-iraq war (1980) or iranian revolution (1979) or six day war (1967) or black september (1970) or yom kippur war (1973) but just after baathists took power in both syria and iraq (1963) and some time after coup in iran (1953), suez crisis (1956) and nasser taking power in egypt (1952)

[-] fullsquare@awful.systems 36 points 3 weeks ago

at least he didn't say he "fell on it" and it was totally an accident

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[-] fullsquare@awful.systems 107 points 1 month ago* (last edited 1 month ago)

the problem is that there is natural (as in, unmodified) cheap generic insulin available, it's just that it sucks compared to everything else. you see, insulin is a peptide that is supposed to appear, do some signalling, then disappear and unmodified insulin copies this thing exactly. the problem is, most of the time when peptide is supposed to work as a pharmaceutical, you don't want to do that, you'd like insulin to last longer than usual, which means changes to it that make breakdown slower, or adding something that makes it stick to albumin, which has similar effect because it hides insulin somewhere enzymes can't reach it and also it makes it start acting slower. this means less frequent dosing and less changes in insulin activity over time. there are also other insulins that start acting faster than natural, and this is also due to a couple of modifications in its structure

for another example, ozempic was not the first drug in its class, it's also a modified peptide, and it can be injected s.c. once a week, compared to previous iteration (liraglutide) that requires daily injections. if natural peptide is injected i.m. instead, its halflife is half an hour, and in serum it's only two minutes (it gets released a bit slower than it is metabolized)

manufacturing costs are about the same for any variant, most of it is in purification. patents for a couple of these have expired anyway by now, but if manufacturing is limited then price can be set arbitrarily high (see daraprim)

[-] fullsquare@awful.systems 43 points 6 months ago* (last edited 6 months ago)

yeah all while ~~being a high school dropout~~ he never went to high school

[-] fullsquare@awful.systems 33 points 7 months ago

idk if cult owned far right rag has that much pull (it's not washington post, owned by bezos)

[-] fullsquare@awful.systems 52 points 7 months ago

Maybe their idea is that publicly embarrassing oligarch boss of that company would be more effective in getting them to either use source code or buying a license

[-] fullsquare@awful.systems 34 points 8 months ago

i'm convinced that rhyming slang is just 19th century coal mine brainrot. you cannot change my mind

[-] fullsquare@awful.systems 32 points 9 months ago

musk and thiel narrowly avoided death in 2000 car crash. can you imagine what could have been?

[-] fullsquare@awful.systems 36 points 9 months ago

death of millions for profit - solid business practice, congratulations and see you again at next shareholder meeting

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fullsquare

joined 9 months ago