I don't get it?
lysdexamphetamine (Vyvanse) is an interesting prodrug version of Adderall that often gets joked about by Felix & a low dosage might address both the short half life of Ritalin while not keeping you too wired to sleep.
The strategy for Adderall XR is having slow release encapsulation, plus different amphetamine salts which take varied amounts of time to become active.
Vyvanse instead attaches a lysine amino acid to the amphetamine molecule, rendering it inert until an enzyme in your bloodstream cleaves off the lysine, yielding the active form.
This prodrug strategy eliminates variables that might affect the release rate of the active drug from an XR capsule before it hits your bloodstream, meaning you get a "spikier" release profile instead of a low & slow consistent dose curve. Variables like a lower stomach pH, which promotes quicker degradation of encapsulation material or how fast the various salts dissociate from the active amphetamine molecule. With the lysine prodrug it doesn't matter how much of the prodrug enters your bloodstream, it's release rate is tied to how quickly that enzyme can cleave the lysine off the amphetamine.
Dr. Spoon's more credentialed than my washed out academic career; my hating has been defeated by meritocracy!
The ghosties scared me as an 9 year old.
Not to mention meeting standards of purity and formulating your medication so it's shelf stable and the active pharm ingredient can be distributed within the body effectively once the medicine is administered.
I've had similar thoughts as these jokers but with using bioreactors. Each time I conclude that the solution is a centralized manufacturing facility owned by workers to effectively produce at scale (and ensure you don't poison people).
Sure, you're not gonna build that misoprostol plant in Texas, but there's other options to obtain properly-manufactured medication before you drink a mystery brew cooked up by an anarchist squatter named Spoon.
Absolutely, and I don't see biohackers offering up cheap NMR or MS/MS detectors to solve the common issue of inadvertently making side products like MPTP when attempting to cook up MPPP or whatever, consequently injecting Parkinson's into yourself. So you're still bound by the enormous costs of getting an analytical lab stood up, despite using "AI" assisted synthetic software to substitute for real verification of each purified intermediate product. Also my other chem friend & I think that Vinni guy is an annoying ted-talk dude fwiw.
Never knew TLC was publically supported or distributed! As a youngish old who enjoyed Junkyard Wars, I remember seeing the slopification in real time.
Also yeah I think the one milf who tried that ended up making it to the finale
Back when the Signal org used to be called Open Whisper Systems it received grants and auditing from the Open Technology Fund which, at the time, was still a part of Radio Free Asia.
https://web.archive.org/web/20150521181458/https://www.opentechfund.org/project/open-whisper-systems
Zaku 1 train
Yeah IV administration is definitionally 100% bioavailable; there might be some degree of the IV drug effluxing from the bloodstream, across the gut lumen, back into the intestines where orally administered charcoal could absorb it. However orally administered drugs will definitely be absorbed by oral charcoal
livestreamedcollapse
joined 1 year ago
Gotcha, I didn't consider the video call aspect cause my grillings were in front of 10 of my peers where I had to draw out the electron pushing mechanism for how the molecule I was researching produces hydrogen peroxide.
I did get it right after like 20 excruciating minutes standing in front of the whiteboard reasoning out the mechanism, but it was never previously taught to me by my PI.
The livestreamed collapse name is based on some old meme about how the future sucks & the only cool technology we have is some pocket screen to doomscroll the collapse of society & climate with.