I'm not gonna go into all the details about colonial history and present day issues in Canada because that's a huge topic and something a person needs time to digest and be open to learning, but in short, Canadians use 2S in front of/as a part of the acronym as a way to recognize and honour the oldest and one of the most marginalized and at-risk groups of people in Canada (two-spirit Indigenous individuals).

That being said (as you can see from my other comments) I often switch between using 2SLGBTQ+, LGBT+, queer, and many other forms of the acronym. It's a personal choice and I'm not going to dictate how other people refer to the community. I'll also note that the term 2SLGBTQI+ is the official term in my country (again, we include the 2S in the spirit of reconciliation)