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Dunning-Kruger
(lemmy.dbzer0.com)
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this post was submitted on 14 Mar 2025
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https://static.scientificamerican.com/sciam/assets/File/Pitch_sketch_final.png?w=2000
This is the best resource I've seen to show things relatively simply.
The TL;DR is that a whole "Y" chromosome isn't exactly responsible for "maleness", the SRY gene is. It's normally on the Y chromosome, but mutations can occur placing that gene onto the X chromosome. Inversely, someone could inherit a Y chromosome without that gene, in which case they would develop with female traits.
It's not considered trans because someone with 46XX plus the SRY gene would develop male genitalia, be identified as male at birth, and likely identify themselves as male. For some types of these conditions, there are plenty of people walking around with no clue that their chromosomes don't match their gender.
Disclaimer: I'm not a geneticist, so i could have explained something a little off.
I'm also not a geneticist but I did study genetics for a while and that's pretty much what I remember learning, so you're good.
The books Mutants: On Genetic Variety and the Human Body by Armand Marie Leroi explains it all very well and touches on many other related genetic conditions like the Klinefelter syndrome (XXY). It's an incredible read all around that really opened my eyes to how malleable biology is.