If done correctly, it will not have a negative impact on the joints. Dampened running shoes and starting really slow are important. Movement will keep your knees healthy. The strengthened muscles will help when you lift heavy weights. Running is also one of the best ways to loose weight, which will reduce pressure on the knees in return.

Of course there are exceptions when running isn't a great idea, like high obesity, chronic pain or injuries.

If running isn't your thing, biking or swimming could be nice alternatives.