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submitted 2 weeks ago by cm0002@lemmy.world to c/science@lemmy.world
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[-] GargleBlaster@feddit.org 107 points 2 weeks ago

I'll read the publication in the coming days and report back, but don't get your hopes up. There's a "breakthrough" in cancer research every few months and it leads to nothing. And this study was done in mice which are a bit different to humans (citation needed)

[-] iopq@lemmy.world 48 points 2 weeks ago

They cured hair loss in mice at least twenty times now and we still have bald humans

[-] remotelove@lemmy.ca 57 points 2 weeks ago

They should probably find a way to turn humans into mice. It's a shame to leave billions of dollars on the table like that.

[-] WoodScientist@sh.itjust.works 31 points 2 weeks ago

Might be a good concept for a sci fi story actually, probably a comedic one. Scientists learn how to cure any disease and reverse aging, but only for mice. Conveniently for plot reasons, they also figure out how to turn people into mice and back. You can get any disease cured or become young again...but you have to spend three months as a mouse.

[-] MegaUltraChicken@lemmy.world 7 points 2 weeks ago

Someone that knows what they're doing: I will watch this show.

[-] turtlesareneat@discuss.online 5 points 2 weeks ago

Is Anne Hathaway coming back as the grand witch?

[-] vestigeofgreen@lemmy.dbzer0.com 4 points 2 weeks ago

I know of a short story on becoming a mouse, but that one's focus is something euthanasia adjacent.

[-] Zirconium@lemmy.world 3 points 2 weeks ago

I cannot remember what but I've heard of mention of a story where because there's so many cures of disease for mice that they take over the world or something. It's such a faint mention sorry

[-] WoodScientist@sh.itjust.works 6 points 2 weeks ago

Pinky and the Brain. Obviously.

[-] Dicska@lemmy.world 3 points 2 weeks ago

Fuck that, just implant those mice on my scalp.

[-] Lost_My_Mind@lemmy.world 6 points 2 weeks ago

Why do we not simply transplant the hair from the mice, onto the humans?

[-] WoodScientist@sh.itjust.works 13 points 2 weeks ago

To avoid rejection of the hair follicles, simply glue live mice to the top of your head.

[-] ikidd@lemmy.world 3 points 2 weeks ago

This sounds like a ChatGPT response from the early days.

[-] gibmiser@lemmy.world 1 points 2 weeks ago
[-] kurwa@lemmy.world 3 points 2 weeks ago
[-] FauxPseudo@lemmy.world 2 points 2 weeks ago

"Mice lie and monkeys exaggerate."

[-] OpticalAccount@aussie.zone 39 points 2 weeks ago

I think this is overly negative. There have been multiple significant advances in cancer treatment over the past 10 years. It just depends which type you get.

[-] jj4211@lemmy.world 7 points 2 weeks ago

Maybe overly negative by saying they come to "nothing", but if you trace those advances back to their initial press release stage, they generally way ovehype it.

Here we have what is being heralded as maybe a universal response to any and all cancer. That would be a shockingly amazing deviation from basically all the cancer research to date. It's possible and wonderful if true, but generally the research falls short of the initial press coverage, even if it amounts to something.

[-] chosensilence@pawb.social 20 points 2 weeks ago

while you're not wrong i do want to reiterate that mRNA vaccines are likely going to be how we treat and cure cancers so there is precedent at least for this to be massive news. if not this there will likely be a real announcement one day.

[-] tburkhol@lemmy.world 17 points 2 weeks ago

The likelihood that all cancers express a common surface marker that is never expressed by any non-cancerous cell seems pretty low. Not a cancer biologist, but there's all kind of different genetic paths to cancer - why would they all cause some specific molecule to be expressed and why would no other cell ever use it?

[-] AmidFuror@fedia.io 21 points 2 weeks ago

Your instincts are correct. The approach in the paper is more complicated than this. Here is the abstract:

Abstract The success of cancer immunotherapies is predicated on the targeting of highly expressed neoepitopes, which preferentially favours malignancies with high mutational burden. Here we show that early responses by type-I interferons mediate the success of immune checkpoint inhibitors as well as epitope spreading in poorly immunogenic tumours and that these interferon responses can be enhanced via systemic administration of lipid particles loaded with RNA coding for tumour-unspecific antigens. In mice, the immune responses of tumours sensitive to checkpoint inhibitors were transferable to resistant tumours and resulted in heightened immunity with antigenic spreading that protected the animals from tumour rechallenge. Our findings show that the resistance of tumours to immunotherapy is dictated by the absence of a damage response, which can be restored by boosting early type-I interferon responses to enable epitope spreading and self-amplifying responses in treatment-refractory tumours.

[-] captainlezbian@lemmy.world 11 points 2 weeks ago* (last edited 2 weeks ago)

Eh a lot of them save some lives. Its just cancer is really good at killing people and there are a lot of types of cancer

[-] Dudewitbow@lemmy.zip 2 points 2 weeks ago

It's why I start following it myself when it gets to the human trial stage and less the breakthrough stage. There, you make the assumption that they have a plan and are much more confident in the product.

[-] HugeNerd@lemmy.ca 1 points 2 weeks ago

How about fusion power and room temperature superconductors...

ITER is still well under way as far as fusion goes. I doubt room temp super conductors will ever be a thing though. If we can get a metalic material which superconducts above the boiling point of nitrogen then that will be world changing enough.

[-] HugeNerd@lemmy.ca -1 points 2 weeks ago

LOL. ITER is not and has never been meant to be a fusion power plant. That would be DEMO.

Don't hold your breath.

https://en.wikipedia.org/wiki/DEMOnstration_Power_Plant

Fusion power will never, ever happen. Ever.

[-] untorquer@lemmy.world 2 points 2 weeks ago

Yeah just wait for the oil/LNG and helium reserves to run out. 🫠

[-] HugeNerd@lemmy.ca 0 points 2 weeks ago

Yes, I'm sure something as simple and resource-light as a fusion reactor will be exactly the thing we'll be able to build when the oil runs out.

[-] untorquer@lemmy.world 1 points 2 weeks ago* (last edited 2 weeks ago)

Oil/LNG not likely to be exhausted in our lifetime, nor do we seem to have the global political willpower to do enough about climate change or perturb capital. Furthermore, the article talks about a lack of VC finding making it unlikely to be viable in the mean time. This is the basis of the sardonic statement in agreement with your comment but also intending to cast a political light on the concern from my end.

this post was submitted on 19 Jul 2025
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