I am expecting a lot of Disco Elysium, here...and nothing wrong with that!
A video gaming student organization I was once part of actually had a vote on their favorite sayings. The winner was the evergreen "Perhaps the same said could be said of all religions..." from Castlevania: Symphony of the Night! https://www.youtube.com/watch?v=OMTizJemHO8
Later we had a second voting, which decided on the cult classic Trio the Punch's "BAD CHOICE"! https://youtu.be/rIPtzZHJnkg?t=454
My personal favorite? It's hard to say...but hey, that's what the scientist in Half-Life can comment, word to word! So maybe I'll put forward, said by the aforementioned: "My god, what are doing!?"
Tl;dr: Check title.
Darkest Dungeon 1 & 2 are full of gems. "Slowly, gently. This is how a life it taken." "Many heroes fall in the face of chaos. But not this one; not today." "At one point he was mourned. Now he's just... gone."
"And now the true test. Hold fast! Or expire."
My favorite is "Monstrous size alone has no intrinsic merit. Unless inordinate exsanguination be considered a virtue."
Great line. And according to the Flagellant, it appears to be a virtue.