Yeah, even just something like movement involves the whole body. The inner ear and stomach are a couple of obvious movement feedback areas, but real movement affects every cell in your body. When they don't agree, it's easy to get disoriented plus there can be nausea.

I feel very lucky that I can move around in a VR game with a controller and not feel sick, but I'd love to be able to feel the acceleration in Gran Turismo. I think not feeling the movement is why I can't go into autopilot in the game like I can while driving for real. I have to pay attention at every corner and need the gear indicator (or memorization) to know how much to slow down. I never have to check my speed on corners when driving a real car, though manual transmission might help with that (but if I drive an auto, I'm still not checking the speedometer on corners).