Absolutely! Additionally, morning sun is another great way to regulate your circadian clock and let your body start its internal timer for melatonin release.

In the winter, I use a light box for seasonal affective disorder, and in addition to feeling much more energized, I find it helps me get more consistent sleep!

That’s great! I really do think 1-1.5mg is the upper limit anyone should use, although it’s still higher than free melatonin concentration in your brain it’s a much more reasonable dose in comparison.

And I think most people who don’t understand melatonin go straight for the 20mg, so we’re probably talking 60+.

It really blows my mind that in this day and age there are no regulations or at the very least warnings or guidelines regarding melatonin supplements.

The gap in FDA policy for prescription drugs vs supplements is vast. Supplements have very few regulations and restrictions that create a lot of potential issues for the uninformed consumer.

That’s a great point! You’re definitely right. I’m seeing somewhere between 10-30% depending on patient population.

That being said, since we are naturally releasing .5mg, another .5mg is already double the normal concentration.

Another major point of consideration though would be formulation, as that is going to have a large effect on the half life of the dose in your system. Even if bioavailability is around physiological concentration at 5mg, the duration of the exposure being much longer than the time it takes for natural release would still have negative impact.

All this being said, definitely never a reason to go above 5mg

Quetiapin is an antipsychotic medication, not the same as melatonin which is a naturally occurring hormone.