Ohh so melatonin leads to adenosine production, which caffeine blocks. so NO SLEEP is the smart bet. that makes a lot of sense, yeah! and when you think about it, coffee at night is gonna make for poor sleep no matter how much melatonin you take.

That’s a great point! You’re definitely right. I’m seeing somewhere between 10-30% depending on patient population.

That being said, since we are naturally releasing .5mg, another .5mg is already double the normal concentration.

Another major point of consideration though would be formulation, as that is going to have a large effect on the half life of the dose in your system. Even if bioavailability is around physiological concentration at 5mg, the duration of the exposure being much longer than the time it takes for natural release would still have negative impact.

All this being said, definitely never a reason to go above 5mg

That’s great! I really do think 1-1.5mg is the upper limit anyone should use, although it’s still higher than free melatonin concentration in your brain it’s a much more reasonable dose in comparison.

And I think most people who don’t understand melatonin go straight for the 20mg, so we’re probably talking 60+.

It really blows my mind that in this day and age there are no regulations or at the very least warnings or guidelines regarding melatonin supplements.

The gap in FDA policy for prescription drugs vs supplements is vast. Supplements have very few regulations and restrictions that create a lot of potential issues for the uninformed consumer.

Absolutely! Additionally, morning sun is another great way to regulate your circadian clock and let your body start its internal timer for melatonin release.

In the winter, I use a light box for seasonal affective disorder, and in addition to feeling much more energized, I find it helps me get more consistent sleep!

Quetiapin is an antipsychotic medication, not the same as melatonin which is a naturally occurring hormone.

My understanding of melantonin is its something you wanna regulate and spread out, like maybe once a week. When I took it in combination with a zinc pill, man I would be in walking dream mode before I even got to my bunk.

I did some reading at the time about the zinc and melotonin, and I could be confusing the mexhanism and effects of the two.

Or I might be entirely wrong and I thank you, and you other guys for calling me out.

I am too lazy to read up on this right now so while I would be wary of combining the two, it might be ok and I might just be wrong .

I have had a long day and gonna zonk now without any supplement heh. Thanks for replying, I prefer to be corrected and its always fun learning I have been wrong my entire life about something, heh

Certainly possible, but I'm sort of a textbook mild case of ADHD, just with the side case of insomnia being fairly prominent (which was true even before medication). Everybody reacts to medication in different ways, so I've just found I have to rely on coping strategies more than medication for my case. It's not a big deal and I'm at a point in my life where I can manage my ADHD symptoms in a way that doesn't affect my life too much. So for me, the side effects of the medication exacerbate my preexisting insomnia to the point that the drawbacks of adderall outweigh the benefits for my particular brand of ADHD.

No it's IR, but taken 20 mg in the morning and then 10 mg in the early afternoon. It just always wound up with the physical effects lingering much longer than the mental effects, so if I tried skipping the afternoon dose, then I'd wind up totally scattered and useless from about 3PM on.

The XR once in the morning worked a little better, but for whatever reason didn't really help the same way and I still had the insomnia from it.

It’s very presumptuous to rule out 350 decaf coffees.

So... They want their heart to explode.

Super speed to heaven

/s doesn't mean sarcastic.

/s

Sure, what could go wrong?

Taking vitamin D supplement (which anyone over 45° latitude should) doesn't make me more tired tho.