669
There can be only one winner
(lemmy.world)
you are viewing a single comment's thread
view the rest of the comments
view the rest of the comments
this post was submitted on 19 Sep 2024
669 points (98.5% liked)
Memes
8407 readers
754 users here now
Post memes here.
A meme is an idea, behavior, or style that spreads by means of imitation from person to person within a culture and often carries symbolic meaning representing a particular phenomenon or theme.
An Internet meme or meme, is a cultural item that is spread via the Internet, often through social media platforms. The name is by the concept of memes proposed by Richard Dawkins in 1972. Internet memes can take various forms, such as images, videos, GIFs, and various other viral sensations.
- Wait at least 2 months before reposting
- No explicitly political content (about political figures, political events, elections and so on), !politicalmemes@lemmy.ca can be better place for that
- Use NSFW marking accordingly
Laittakaa meemejä tänne.
- Odota ainakin 2 kuukautta ennen meemin postaamista uudelleen
- Ei selkeän poliittista sisältöä (poliitikoista, poliittisista tapahtumista, vaaleista jne) parempi paikka esim. !politicalmemes@lemmy.ca
- Merkitse K18-sisältö tarpeen mukaan
founded 2 years ago
MODERATORS
Bioavailability of oral melatonin is very poor though. IIRC it's about 10%, so that 5mg sounds about right.
That’s a great point! You’re definitely right. I’m seeing somewhere between 10-30% depending on patient population.
That being said, since we are naturally releasing .5mg, another .5mg is already double the normal concentration.
Another major point of consideration though would be formulation, as that is going to have a large effect on the half life of the dose in your system. Even if bioavailability is around physiological concentration at 5mg, the duration of the exposure being much longer than the time it takes for natural release would still have negative impact.
All this being said, definitely never a reason to go above 5mg