To shreds you say...

Farnsworth: "Remember to take your anti-pressure pills everyone!"

Fry: "I can't swallow this!"

Farnsworth: "Good news! It's a suppository!"

I quote "Tell them I hate them" all the time, especially at work when someone does something unexpected that forces me to fix it.

From Fry and the Slurm Factory

you sound like my tennis instructor

I don’t want to live on this planet anymore.

IT CAN DO OTHER THINGS! WHY SHOULDN'T IT?!

Leela: “He’s been in there a long time. I’m going in after him!”

Farnsworth (exasperated pointing): “Professor. Lava. Hot!”

"I don't want to live on this planet anymore"

Sweet Zombie Jesus

"And here's where I keep assorted lengths of wire."

"To shreds you say? How's his wife holding up? To shreds you say?"

"I can, but that's because I'm not a penniless hippie!"

Whoa fire indeed hot

They say madness runs in our family. Some even call me mad. And why? Because I dared to dream of my own race of atomic monsters, atomic supermen with octagonal shaped bodies that suck blood

Heather: Sir, it's not necessary or wise to be naked.

Farnsworth: You sound just like my tennis instructor!

It's dolomite, baby!

Professor Farnsworth: You can't just waltz into the Central Bureaucracy. It's a tangled web of red tape and regulations. I've never been, but a friend of mine went completely mad trying to find the washroom there.

Leela: Then we'll need a guide, someone who's been there before.

Professor Farnsworth: Oh, I've been there. Lots of times. [laughs maniacally]

Well, I am already in my pajamas

FARNSWORTH:
Dear Lord, that's over 150 atmospheres of pressure.

FRY: How many atmospheres can this ship withstand?

FARNSWORTH: Well it's a spaceship, so I'd say anywhere between zero and one.

Edit: Sorry I'm not sure why my comment was added as a reply to the parent comment.

What's the matter compressor?

Nothing's the matter, now that I fixed the matter compressor.

You changed the outcome by observing it!

Fuck you everyone!