As I always say when this comes up...
If you've got a plan to make it happen before the next election, I'm on-fucking-board. Otherwise, harm reduction is not morally optional when the question is fascism vs. anyone less fascist, including neoliberal ghouls. The question of significant reduction of harm, even if in a still-fundamentally-fucked-system, is not something that can be dismissed on grounds of ideological purity, unless one holds that personal ideological purity with no concrete gain for the ideology's actual goals (and potentially significant damage to the cause) is worth the lives of millions of marginalized peoples.
Those in polities with less-fucked politics, electoral systems, and executive power than the USA might find it less necessary at present, but I would argue that the point is broadly applicable even there.

