The first two have emphasis that imply something different than a simple question. Like you are asking a bunch of people individually, and you are directing each question at a specific person.
The last one would maybe be like, if the person did something weird, and you were sarcastically asking where the are from, to imply that they were raised by wolves, or something like that.
Point being, yes, you can ask like that, but it has different connotations than a simple question, which I think is where you would use the rising intonation.
I thought I read that grapefruit can also cause problems with certain ones