Closest I've come to this was twice, both from the same doctor. She was actually my favorite primary doctor I've had, up until my insurance changed and I could no longer see her without it being cripplingly expensive.

Looking at my lab work results, one time she goes, "This is really interesting, you've got all kinds of stuff going on, don't you?" and another was simply "Woah!"

Even if she wasn't generally pretty funny, would still be my favorite, since she pretty much nailed down diagnoses for several issues that had been ailing me for years within the first couple appointments, was great with giving me referrals and fighting with insurance about "Yes, this really is necessary, it's in your coverage agreement, so shut up and pay!" and got me back up to some semblance of full health in a matter of months. Like, exhaustion and joint pain so bad, I couldn't walk down the single flight of stairs to leave my apartment some days and migraines that made me have to lay in a dark room for an hour, to now just being generally always a bit more fatigued than I should be given the amount of stuff I do in a given day.