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Common blood pressure drug shows promise for treating ADHD symptoms
(www.psypost.org)
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this post was submitted on 22 May 2025
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ADHD
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This is really interesting. As I was reading the article I was wondering how they were going to wring money out of it, as amlodipine is off patent. Then I got to this part:
Classic big pharma. Slightly tweak an existing drug in an insignificant way so that you can get a new patent on it and charge exorbitant prices.
Is it going to still work on blood pressure? I don't like the idea of taking meds because I want to resolve things with diet and exercise when possible, and I'm afraid of side effects. But if I eventually have to start taking a blood pressure medication and the side effect is it makes my ADHD better, I could get on board with that.
They're reformulate it and call it something new. They'll still sell amlodipine for blood pressure.
Clonidine can do that
On the bright side, off-label drug prescription is legal and ethical, if a bit bizarre.
I have Adha and hypertension. As such I have an unused bottle of amlodapine at home. I'll take it and report back
Update: it's been 5 days and as much as I thought this medicine wouldn't do anything to help my adhd, it has. I'm on the lowest dose of amlodapine possible as such I need to talk with my Dr to see if i can increase. The only downfall is, is that it doesn't help with energy levels like sone of the stimulants do, however it definitely helps with motivation and concentration. I'll continue on until I finish tge bottle and will make a final update in 24 days. Early indications are promising though
There’s no reason to believe those changes aren’t needed to work more effectively though, especially if it’s trying to be classified as an ADHD medication. Changing one molecule really can fundamentally change a drug, if it’s the right molecule changed the right way, it’s not inherently a cash grab, there’s not enough info here about the chemistry and its applications to make that call
This is correct. Amlodipine is very effective as a blood pressure medication, but it doesn't get through the blood-brain barrier which is one of the biggest hurdles for any psychiatric or neurologic medication. There's an entire special sub-type of brain cells that control what actually makes it out of the blood and to the neurons and getting things past that barrier is quite difficult.