Indeed Artificial Intelligence (AI), including machine learning, autonomy, and related advances, ($655.23 million) investments will bring together numerous fields of scientific inquiry—including computer and information science; cognitive science and psychology; economics and game theory; education research; engineering and control theory; ethics; linguistics; mathematics; and philosophy—to advance the frontiers of trustworthy AI, including advancing perception, learning, reasoning, recommendation, and action in the context of specific fields and economic sectors. NSF investments are needed to develop new foundational AI theory and implementation techniques, as well as novel AI methods that are inspired by use cases in specific application domains and contexts.