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[-] BodyBySisyphus@hexbear.net 9 points 3 days ago

Results indicated that the mice that received an initial low dose of psilocybin of 5 mg/kg, followed by a monthly high dose of 15 mg/kg for 10 months, had a 30% increase in survival compared to mice who hadn’t received any.

So if we take a standard 80 kg adult male, 80 * 15 mg = 1.2 g, which sources indicate is enough for a standard trip. That's also like almost half an ounce of dried mushrooms. Time to start tripping... for science.

[-] BodyBySisyphus@hexbear.net 8 points 3 days ago

Yeah, the paper is talking about pure Psilocybin. I double checked and the rule of thumb is around 1% psilocybin by dry weight so I was actually off and you'd need closer to three ounces.

[-] Castor_Troy@hexbear.net 4 points 3 days ago* (last edited 3 days ago)

(15 mg psilocybin / 1 kg body weight) * 80 kg body weight = 1200 mg psilocybin

1200 mg psilocybin * (1 g psilocybin / 100 g dried mushrooms) = 12 g dried mushrooms

I think it's 12 grams dried mushrooms, which is almost half an ounce, like you first said.

[-] Maturin@hexbear.net 7 points 3 days ago

Shouldn’t it be 1200 mg / 0.01 = 120 g of dried mushrooms?

[-] Castor_Troy@hexbear.net 2 points 2 days ago

(15 mg psilocybin / 1 kg body weight) * 80 kg body weight = 1200 mg psilocybin

1200 mg psilocybin = 1.2 g psilocybin * (100 g dried mushrooms / 1 g psilocybin) = 120 g dried mushrooms

There we go.

[-] Castor_Troy@hexbear.net 2 points 2 days ago

Thank you. I was staring at it and knew the units weren't canceling out. That's an insane dose though.

[-] Maturin@hexbear.net 4 points 2 days ago

Even the “low dose” is the equivalent of almost 2 oz per dose. Those mice got to convene with the mice gods on the reg I’m sure.

[-] propter_hog@hexbear.net 4 points 2 days ago

Boofing a whole tray of penis envy shrooms... for science

this post was submitted on 24 Jul 2025
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