Southern Florida? Like the man said: Florida: the more North you go, the more South it gets. Orlando seems mostly OK. Big city, opportunities, and there's a NASA space center and launch facility not too far.

My mom lives there, and that's about the limit of my knowledge. I will personally never again willingly live south of the Mason-Dixon line.

Oh, I hear that if you stay out of the little handle at the bottom, Missouri is nice. A friend from there once told me that if they'd cut off that handle and give it to Arkansas, it'd raise the average IQ of both states. Never been there, myself.

Lots of places in Oregon and Washington are great; large swaths are not, but if you're not prone to SAD, there are great towns in the Willamette Valley: Corvallis, Eugene, and Ashville down on the California border. Also, California is enormous. N California is very different from S California, and the coast is enormously different from the interior. It's a huge state, and painting it with a single brush is like saying Georgia, the Carolinas, Virginia, Washington DC, and Pennsylvania are all the same. It's seriously about the same area as all those put together, lengthwise, at least. The greater LA/San Diego area alone is almost as big as your entire state. But the Pacific Northeast is wet if you live in the Valley, and there isn't much in the way of big cities east of the Cascades.

How about Boise, ID? Good size college city, lots of microbreweries, lots of outdoor recreation, pretty great weather if you like hot, but you get snow in the winter, too. Plus nearly half the state is national park; fantastic backpacking.

Most of these places I mentioned specifically lean liberal, although when you venture into rural areas it gets red pretty quickly, like anywhere. An exception is Orange County in CA, which is full of really crazy red-hatters. But it sound like you've already ruled out at least part of CA, and "insufferable" makes me think you're thinking specifically of S Cal.

Eugene is, or used to be, fantastic. Extremely liberal, and not trust-fund hippie style. Decent sized to be entertaining. You just have to put up with the weather and hippies, or whatever hippies have mutated into with successive generations. Pot's legal in OR, too, if that's your bag.

Bend, OR is one of the best places in the planet if you're sporty. It's high desert, but smack up against the mountains. In the summer, people rock climb and bike. In the winter, they ski Mt Bachelor. There's fishing and camping, and at one point it had more restaurants per capita than any other city in the US. There's no humidity. At all. Very pretty town. A 4 hour drive north, and you're in Portland, OR, which isn't what it used to be and has been having problems, but is still a large metro area with lots to do and a fantastic science center. 2 hrs West through the mountains is Salem, the capital, which frankly sucks; or or 3+ hours SW is the aforementioned Eugene. A couple hours south is Crater Lake. A couple three more hours and you're in the N California Redwood forest. Oh, and if you do speed through So-Lame (Salem), another 1.5 hours and you're on the Oregon coast, so 3-4 hours from Bend to the coast, mostly through a fantastic, amazing mountain range (and then the Valley and then the smaller coastal range).

If you want to stay on the E coast, I recommend the greater Philadelphia area. From there, NYC is a 3hr drive. The Jersey shore is a 3 hr drive. Washington DC is a 3 hr drive. Gettysburg is a 3 hr drive. Williamsburg, VA - possibly my favorite place in the US - is a 4-ish hour drive (depending on DC traffic). Plus, you can get to almost any of the coast cities from Philly by train, if you're willing to sacrifice a couple more hours. Pennsylvania wasn't my favorite place to live, but if you can stand living in S Carolina I'm sure it'd be fine for you.

Honestly, you might consider Minneapolis. It does get cold in the winter (-50F is the coldest I've experienced), but The Cities are fantastic, full of Art Deco architecture, and end-summer temps can hit the 100's. In September, any of the literally over 10,000 lakes are bath-water warm. And we don't have copperheads. The great lakes are close; we're practically in the center of the country, so flying anywhere in the continental US is a 4-hour flight or less. The Cities are very progressive - again, you drive an hour outside and it's Trump signs everywhere - par for the course - but within The Cities it's quite nice. And the bike paths are incredible; miles and miles, and much of it completely off-road - at some point they took all the old industry rail lines and turned them into maintained bike and foot paths. It's really quite remarkable. And the metro system isn't half bad, for a US city. The humidity gets oppressive, but, again, you're surviving S Carolina so I don't think that'd be a problem for you.