If done right no, there's no reason other than noise, size, and power usage. It also might pick up small things which could impact the components if the fans are strong. At worst it may push them out of place. That last two are pretty unlikely though.

It my be hard to ensure airflow as small pockets of a may form due to turblance that can't exit the system however.

All in all though there's no reason why a big ass fan couldn't work and if airflow to the heat generating components is right it would be better at cooling