Thank me later... (reddthat.com)

submitted 1 month ago by lemmydividebyzero@reddthat.com to c/lemmyshitpost@lemmy.world

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[-] daannii@lemmy.world 3 points 1 month ago* (last edited 1 month ago)

These drugs release endorphins not dopamine.

Dopamine is not a feel-good neurotransmitter.

It's widely misunderstood and misapplied.

Dopamine in the brain is actually more tied into motor control and function.

A loss of dopamine producing neurons causes Parkinson's. Interestingly, giving parkinson patients drugs to boost dopamine gives them schizophrenia like symptoms. Dopamine is not related to the reward feeling. Please stop pushing this narrative. It's probably one of the most annoying misunderstanding of modern neuroscience in the last few years.

Dopamine is implicated in part of the reward pathway but it is not the reward feeling.

Instead it is part of conditioning expectations for drug use related to behaviors that get the drug.

It's kind of complicated but again. It 100% is not a feel-good neurotransmitter.

It is not what makes you enjoy anything.

You are getting confused with endorphins.

And euphoric effects of drugs. Which are independent from dopamine.

[-] Cevilia@lemmy.blahaj.zone 1 points 1 month ago

So you're telling me that four orgasms is roughly equivalent to doing cocaine?

Hold that thought.

[-] tias@discuss.tchncs.de 1 points 1 month ago* (last edited 1 month ago)

The trick is to time the cocaine and crystal meth ingestion so that they peak at the same time that you orgasm, leading to an 80% * 300% * 1400% = ~~7460%~~ 10700% dopamine increase.

[-] Kyrgizion@lemmy.world 1 points 1 month ago

Your permanently burned out synapses will thank you for the vacation.

[-] adhocfungus@midwest.social 0 points 1 month ago

I heard the dev didn't intend for those to stack and it's nerfed in the next patch.

[-] arrow74@lemmy.zip 0 points 1 month ago

I heard there's a flaw in the code meaning they cannot patch the old consumables and have to release a new version instead.

It's unclear if the pre-patch consumables will be usable after the patch or if they'll simply be deleted.

Imo the best move is to collect and sell to the hoarders. Not worth the risk of losing all that time I'd rather be able to buy the new stuff even if it doesn't stack

[-] four@lemmy.zip 0 points 1 month ago

Yeah, I don't want to risk a ban, that's not worth it

[-] Zozano@aussie.zone 0 points 1 month ago

Serotonin Syndrome

[-] MojoMcJojo@lemmy.world 1 points 1 month ago

I experienced a 'mild' instance of this. No f'ing thank you would I ever ever want to go through that again.

[-] starman2112@sh.itjust.works 1 points 1 month ago

girlfriend called... DECLINE! busy whore!

busy with my METH

[-] JasonDJ@lemmy.zip 0 points 1 month ago

Have I been getting really bad coke?

[-] Rai@lemmy.dbzer0.com 0 points 1 month ago

Having had oodles of bad to mediocre coke in my days and then having 90+% pure (tested myself) I honestly think this graph is misleading, and coke is waaaaay higher.

The problem is, meth dumps your serotonin and feels good by itself, while coke requires you to be doing something that dumps your sweet brain chems to really feel good-good. I don’t know the science behind it but it’s been explained to me. Doing coke and sitting around watching a show is meh. Doing blow and playing a stimulating video game or doing a project that feels good or talking your partner’s ear off (and they yours in return) about ridiculous shit feels incredible.

But yeah. If you need to do a couple lines of coke to really feel it, it’s not good. If you’re getting zooted off a couple bumps, that’s the good stuff.

[-] miked@piefed.social 0 points 1 month ago

This person knows coke

[-] Rai@lemmy.dbzer0.com 2 points 1 month ago

Hahaha I had done it a few times during my rave phase but I was almost always disappointed. Like, you gotta do so much of it that it clogs your nose and it goes away so quickly! Then randomly an acquaintance of mine maaaany years later told me they dabbled (understatement) and I learned that almost all coke is complete garbage. A couple bumps had me zooted for like an hour. Remember kids, if it’s already a powder when it comes to you, it’s been stepped on. If you’re getting a shiny chunk that’s almost gummy-feeling, you’re in for a treat.

[-] miked@piefed.social 0 points 1 month ago

One of us!

[-] Rai@lemmy.dbzer0.com 0 points 1 month ago

It’s not even as expensive as people say it is. If it’s not shitty, ya don’t go through a ball in a night! My partner and I still occasionally dabble, and we maybe go through .1-.2 each for a couple hours of zoot.

The test kits are really cool, too. You break a glass ampule and shovel in a tiiiiny bit in. The shade of dark the chemicals turn tells you the purity. I’ve seen it turn a sludgy light-brown watery poo color a long time ago… and I’ve seen it turn black since then.

[-] miked@piefed.social 1 points 1 month ago

Once I found a good supply a ball would last over a week (unless I had some leaches). Before that i occasionally got stuff that did absolutely nothing.

Before the good supply I went home early one night without partying. Friends bought some stuff with fent in it. One friend ended up in the ER. They used paddles to get his heart started again.

Glad to say I no longer indulge.

[-] Rai@lemmy.dbzer0.com 2 points 1 month ago

Jesus! I’m so sorry your friend went through that, that’s awful! I’m very thankful for test strips now… it’s terrifying that something so opposite can just find its way into blow.

I’m glad you’re safe, and I hope your friend is okay now.

Good on you for no longer fuckin with it. My partner and I drink too much but otherwise are mainly sober from substances—we just have some random special days every couple months where we do something fancy and fun.

[-] bitwolf@sh.itjust.works 0 points 1 month ago* (last edited 1 month ago)

Orgasm is 80%, what's 100%?

[-] SCmSTR@lemmy.blahaj.zone 1 points 1 month ago

Orgasm plus cuddles

this post was submitted on 09 Nov 2025

9 points (90.9% liked)

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