I still play civ 5 at least weekly with a few friends. Honestly no mods just all the Gods and Kings and BNW expansions, and whatever DLCs you get when you buy the complete game. I'm at close to 1000 hours on steam, of the group I play with I'm the lowest (one guy has like 3500 hours of Civ V, pretty wild).
Tldr the game still really holds up. Multi-player FFA is still really annoying as people rage quit all the time. But if you get a good group to play with it is quite the game!