Yes. I can't find the original lecture, but here are the lecture notes and the paper that makes the argument that the Drake Equation isn't necessarily a great argument for or against alien civilizations.

Not only are the assumptions in the Drake equation vibes, but if you tune them to get answers that (a) we are alone in the entire galaxy or (b) we are alone in the entire visible universe. There is also the assumptions that we could easily detect a signal for aliens. There's also a compelling argument that we simply do not have enough information to clamp down on the parameters.