I completed the Xbox 360 version of Read Dead Redemption on Xenia Canary some months back with the only enhancements being a 60 FPS unlock patch (I don't think my rig ever really hit 60, in empty wilderness scenes I got around 40-55 FPS and in towns and heavy combat I got maybe 22-30)
as well as some antialiasing and smoothing filters applied to hide jaggies since I didn't think my RX 6600 could've handled resolution upscaling.
I still have Undead Nightmare to beat, but the PS4 and Switch versions got announced while I was getting to the end of the main game, and now that they're out I'm wondering if I should try Switch emulation for the DLC.
I did some quick googling and it seems emulating the Switch version on RyujinX has better performance visuals and less graphics glitches than Xbox 360 emulation, but I'm not sure if my Ryzen 5 5600 and RX 6600 are enough to make it a better option than the 720p with unstable FPS and lighting glitches you get on Xenia.
I have a similar setup to yours, and can offer my experience:
Got a regular clocked ryzen 7 3700x and a radeon rx 5700. I use ryujinx, but only played TotK on it.
my pc just laughed at the 60fps mod but got 30fps at 720p resolution nearly always above ground, and usually in the depths though the depths especially had intermittent times where i was chugging along at only 10fps. I think it was something to do with the cache, but i never isolated the cause.
I would say you'll probably have slowdowns but will generally perform better than my rig which is acceptable if not great for switch emulation
EDIT: other specs that might affect performance:
64G ram
Crucial M.2 hdd
VERY pretty LEDs