A sample size of one is way to small to be actually useful but I've always thought that the solution to the Fermi paradox ("Where is everybody?") is that intelligent life eventually fucks itself and its civilization decays or is destroyed.

Fermi paradox

The Fermi paradox is the discrepancy between the lack of conclusive evidence of advanced extraterrestrial life and the apparently high likelihood of its existence. As a 2015 article put it, "If life is so easy, someone from somewhere must have come calling by now."

Italian-American physicist Enrico Fermi's name is associated with the paradox because of a casual conversation in the summer of 1950 with fellow physicists Edward Teller, Herbert York, and Emil Konopinski. While walking to lunch, the men discussed recent UFO reports and the possibility of faster-than-light travel. The conversation moved on to other topics, until during lunch Fermi blurted out, "But where is everybody?" (although the exact quote is uncertain).

There have been many attempts to resolve the Fermi paradox, such as suggesting that intelligent extraterrestrial beings are extremely rare, that the lifetime of such civilizations is short, or that they exist but (for various reasons) humans see no evidence.