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this post was submitted on 26 Aug 2024
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I'll add that to the list of genes I want knocked out when CRISPR gets good enough.
Eh, it's probably good enough for this. Go for it.
We can do this on isolated cells, but I really don't think we have a way to distribute such a change across the zillions of cells in a human body.
And even if we could, it's not clear how much effect altering the gene after the fact would have. Maybe once your apocrine glands have obeyed the gene and developed a certain way, it's too late.
That said... Sign me the hell up.
isnt crispr itself the way to distribute it?
CRISPR makes gene editing easier, but unless you've got a way to deliver it to every cell, it won't do much unless you're targeting such a small number of cells that it's realistic to have a technician physically inject it into a cell.
That would work for an embryo. Ignoring the plethora of ethical issues and the lack of data on long-term effects, it would probably be pretty easy for a scientist to make the change in an embryo and then go through the normal in-vitro fertilization procedure.
For a whole organism, though, it's more difficult. One obvious solution is a specially modified virus, and that's under research.
There's a lot of stuff here if you want to dive deep:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356196/#sec3-biomolecules-10-00839title
One of the best explanations of this and an actual demonstration of the technology to do this was done In this video on curing lactose intolerance (not permanently).
Whats even crazier is that this video was published 6 years ago and the paper you referenced is 4 years old. With the speed that genetics research is going, both of these are certainly very outdated resources even if the background is mostly the same.
That's pretty impressive. I hadn't even thought oral treatments were possible!
It's amazing.
We can't make enough. And crispr is for inside cells, there is another layer needed for getting it there, like a virus shell for example.
Well, The Thought Emporium made a pill with a virus that modified the genome in at least some of his cells, and made him lactose tolerant for a year and after that he was left significantly more able to handle lactose than before.
So it's absolutely possible to some degree, for some gene manipulation at least.