I took DOC back in the 00s (on purpose) and it was an extremely wild 20-some hours. Second weirdest thing I’ve done (the weirdest is Foxy by a WIDE margin,) but I still had a relatively good time due to having a great and comfortable set and setting. By hour ten, I was VERY ready to be done.

Most drugs/medicines are taken in higher doses because the body filters or neutralizes the compounds so much that only a small portion gets into the blood.

That's still different.

Even if the total quantity of the drug is small in the system once it gets there, it's not the same as how LSD works. The drug, likely because of its similarity to serotonin and size , is readily absorbed into the blood stream and passes the blood brain barrier easily. It is not filtered out to a small percentage of it's original dose like most drugs/medicines.

You surely are aware of this ?

There are very few drugs that can work in small dosages like LSD. As I said, fentanyl is one.

Drugs like DMT /Ayahuasca also can't be ingested unless they are mixed with a maoi inhibitor.

Most psychedelic research chemicals (nbome) are much different than lsd with different pharm and effect properties.

It's possible that LSD is released more quickly on the tongue than nbome drugs. So as soon as it hits the tounge the drug is delivered. I don't think there is research on this. But I'll look into it. I do know that the first trip was caused by a small contact of the drug on someone's hand. That the cleaned off immediately. And it was enough time to absorb a substantial amount of the drug.
I heard women would put on lipstick and smear LSD on the front and kiss police during protest to dose them. If That happened it might support a very fast delivery.
I can't find the source right now to verify the story. I'll keep looking. Maybe I have details wrong. Maybe it was Charles Manson instructing women to do this. Does this story sound familiar to anyone ? I'll have to find the source and verify.

But my point is.

This idea that it's not neutralized in the stomach is false. There is plenty of research on that.

Yes, but... it's really hard to stay focused. Everything is kinda awesome to look at, so I have forgotten about the stars and zoned on my surroundings or my hand or a hundred other things. I like tripping in the woods or at the beach best personally.

You know there isn't much in a single location aside from Wikipedia.

In textbooks I've come across , there is discussion of the pharmacology properties or a brief note about counter culture and general effects.

There is limited research on the drug as it's been black listed for almost 50 years and even now, it's primarily only researched for terminally ill people/mental health. Only a handful of those studies exist and none use double blind controls so the science quality is poor.

I myself am not convinced it has mental health benefits due to the way the drug works. It does however have strong suggestive effects meaning the drug itself promotes placebo/expectation effects.

The lecture I put together for my class (perception and sensation ) pulled info from a wide range of resources.

However there is one organization trying it's best to do modern research and they have done some MRI studies. There was also a study on LSD and synesthesia which sheds a lot of light into the mechanisms. MAPS is the organization. https://maps.org/

They have videos on YouTube with researchers discussing the research and studies they have done. But they mostly focus (last few years at least) on it's use in mental health.

The drug property information I know about is mostly pulled from old research from the 60s before the research bans. A lot was done on animals to understand dosage and half life. The cascade effects of how this drug works are still not really understood. We do know that the drug is similar in structure to serotonin. But there are still a lot of unknowns.

Let me dig around for my resource links. I have a few interesting studies I found when preparing the lecture, including the synesthesia one, and I'll organize it all and I'll put a link up to a g drive with it.

The lecture I did was 3 hrs long about hallucinations with a chunk dedicated to psychedelics. It did rely on other lecture materials to understand or otherwise id just put it up. (It was the final lecture for the class so it referred back multiple times to previous lessons). But maybe I can re-write it a bit. I've honestly been thinking of turning it into a video for a while because there are so few resources out there that review it more broadly. And a hell of a lot of misinformation about hallucinations and psychedelics.

Basically this lecture was on hallucinations and the primary causes and how each of these causes relies on the same root changes in brain processing.

For instance. You are driving on a country road at night. Vigilant to look for deer. Multiple times you were sure you saw an animal near the road but soon realized it was a fence post. Or an old glass bottle reflecting your headlamps. But for a split moment you did see an animal there before you corrected the perception.

What ultimately caused that is what causes hallucinations in other situations. Like schizophrenia and drug use.

So we circle around neuroscience, psychiatry, physiology, and pharmacology. As well as cultural impacts influencing the experience of hallucinations or psychedelics.

This is getting long. Apologies. The lecture is 3 hrs and relies on many other hours of information. It's a big topic.

After re checking this information, I believe I was confusing DMT and LSD properties of not being active when ingested.

I remembered DMT can't be ingested but I was sure it was true for LSD. But I was mistaken. LSD is neutralized by base not acids.

Your stomach acid will definitely neutralize it. But after having it on your tongue for a while the drug has been deposited into your system.

It bothers me that it's a cube and asymmetrical inside.

why is the door off center to the wall?! gah.

(and another thank you, never realized there was an inside you could go inside of, I always assumed it was a sealed tomb.