Yeah memes aside, the "NPC" shit is cover for fascism and justifying the murder of the out-group. Reactionaries are creatively bankrupt, so all they can do is appropriate. In this case, they took stuff from The Matrix (red pill, simulation, etc.) that was an allegory of capitalism and observations of social constructs (gender especially).

It's ironic how they view others as "NPCs" when they're so easily programmed by outrage while being incapable of producing meaningful art.